政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/20725
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 113318/144297 (79%)
Visitors : 51042264      Online Users : 924
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/20725


    Title: Acute Effects of d-Amphetamine on the DRL Schedule Behavior in the Rat: Comparison with Selective Dopamine Receptor Antagonists
    Authors: Liao, Ruey-Ming
    廖瑞銘
    Cheng, Ruey-Kuang
    Contributors: 國立政治大學心理學系
    Keywords: D1 and D2 receptors;IRT analysis;ketamine;pentylenetetrazole;psychostimulant;raclopride;SCH23390;timing behavior
    Date: 2005
    Issue Date: 2008-12-31 10:48:03 (UTC+8)
    Abstract: Amphetamine and it analogs have been shown to affect operant behavior maintained on the
    differential reinforcement of a low-rate (DRL) schedule. The aim of the present study was to investigate
    what specific component of the DRL response is affected by d-amphetamine. The acute effects of
    d-amphetamine on a DRL task were compared with those of the selective dopamine D1
    and D2
    receptor
    antagonists, SCH23390 and raclopride, respectively. Pentylenetetrazole and ketamine were also used as
    two reference drugs for comparison with d-amphetamine as a psychostimulant. Rats were trained to
    press a lever for water reinforcement on a DRL 10-s schedule. Acute treatment of d-amphetamine
    (0, 0.5, and 1.0 mg/kg) significantly increased the response rate and decreased the reinforcement in a
    dose-related fashion. It also caused a horizontal leftward shift in the inter-response time (IRT)
    distribution at the doses tested. Such a shifting effect was confirmed by a significant decrease in the peak
    time, while the mean peak rate and burse response remained unaffected. In contrast, both SCH23390
    (0, 0.05, and 0.10 mg/kg) and raclopride (0, 0.2, and 0.4 mg/kg) significantly decreased the total, nonreinforced, and burst responses. The de-burst IRT distributions were flattened out as shown by the doserelated decreases in the mean peak rate for both dopamine antagonists, but no dramatic shift in peak
    time was detected. Interestingly, neither pentylenetetrazole (0, 5, and 10 mg/kg) nor ketamine (0, 1, and
    10 mg/kg) disrupted the DRL behavioral performance. It is then conceivable that d-amphetamine at the
    doses tested affects the temporal regulation of DRL behavior. The effectiveness of d-amphetamine is
    derived from its drug action as a psychostimulant. Taken together, these data suggest that different
    behavioral components of DRL task are differentially sensitive to pharmacological manipulation.
    Relation: Chinese Journal of Physiology, 48(1), 41-50
    Data Type: article
    Appears in Collections:[Department of Psychology] Periodical Articles

    Files in This Item:

    File SizeFormat
    12.pdf37KbAdobe PDF22045View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback