English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 113648/144635 (79%)
Visitors : 51574207      Online Users : 907
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/20714


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/20714


    Title: Differential effects of dopamine D1 and D2 receptor antagonists on conditioned orienting behavior in the rat
    Authors: Chang, Yea-Huey
    Liao, Ruey-Ming
    廖瑞銘
    Contributors: 國立政治大學心理學系
    Keywords: SCH23390;raclopride;appetitive Pavlovian conditioning;associative learning;acquisition;expression
    Date: 2003-03
    Issue Date: 2008-12-31 10:47:20 (UTC+8)
    Abstract: Brain dopamine (DA) systems are known to be important in regulation of behavior conditioned to
    appetitive stimuli. Nevertheless, despite a large body of evidence showing behavioral deficits in the
    operant conditioning paradigm produced by DA receptor blockade, there have been relatively few
    studies directly assessing behavioral changes in classical conditioning paradigm under this drug
    treatment. By employing an appetitive Pavlovian conditioning task, the present work investigated the
    effects of selective D1
    and D2
    receptor antagonists on the expression and acquisition of the conditioned
    orienting response (COR) and food-cup approach. SCH23390 (0, 0.05, and 0.10 mg/kg) and raclopride
    (0, 0.1, and 0.2 mg/kg) were administered via an intra-peritoneal route in a between-group design. Data
    from Experiment 1 showed that both SCH23390 and raclopride suppressed expression of the COR and
    food-cup approach, but only the impairment produced by raclopride reached a significant level. In
    Experiment 2, with SCH23390 being administered during the acquisition phase, the suppressed COR
    was completely restored in a subsequent (24 h later) drug-free session. In contrast, the suppressed COR
    in raclopride-pretreated groups was only partially restored. These findings support the view that the
    DA system plays a role in the neural substrates underlying this appetitive conditioning. In addition, D2
    receptors are more likely involved in the modulation of learning process of the COR than D1
    receptors.
    Relation: Chinese Journal of Physiology, 46(4), 159-168
    Data Type: article
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File SizeFormat
    p11.pdf102KbAdobe PDF21377View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback