政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/20692

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政大典藏 > College of Science > Department of Psychology > Periodical Articles > Item 140.119/20692

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/20692

Title:	Microinjections of SCH23390 and haloperidol into striatal subregions differentially affect water intake in the rat
Authors:	廖瑞銘;Liao, Ruey-Ming;Yeh, Chung-Ching;Liao, Jui-Jung
Keywords:	haloperidol;SCH23390;microinjection;striatum;water intake;rat
Date:	1996
Issue Date:	2008-12-31 10:45:49 (UTC+8)
Abstract:	The nigrostriatal dopamine neurotransmission system is known to mediate various types of functional behaviors. Systemic administration of dopamine antagonists impairs drinking behavior induced by different dipsogenic agents. The present study was designed to further characterize the potential neural loci for hypodipsia under dopamine receptor blockade of the striatum via local administrations of SCH23390 and haloperidol. Water deprived rats were bilaterally implanted with cannula aimed at either the dorsomedial or ventrolateral striatum (DMS or VLS). Water intake was measured for 30 min after the intrastriatal microinjection. Results showed that the VLS site was more sensitive to DA receptor blockade than the DMS site to affect water consumption. However, only local infusion of haloperidol, rather than SCH23390, into the VLS site significantly reduced water intake. These data indicate that drinking performance can be sensitive to the heterogeneous functions of the striatum associated with specific dopamine receptor subtypes.
Relation:	Chinese Journal of Physiology, 39(2), 117-121
Data Type:	article
Appears in Collections:	[Department of Psychology] Periodical Articles

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