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    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/157164


    Title: 探討CDKL5如何依年齡調控神經興奮性
    Untangling Cdkl5-Mediated Age-Dependent Regulation of Neuronal Excitability
    Authors: 廖文霖
    Contributors: 神科所
    Keywords: 第五型類週期素依賴激酶;早發性癲癇;γ-胺基丁酸;神經發育疾病;基因調控
    CDKL5;early-onset epilepsy;GABA;neurodevelopmental disorder;gene regulation
    Date: 2024-07
    Issue Date: 2025-05-29 11:56:56 (UTC+8)
    Abstract: CDKL5缺失疾患由CDKL5基因突變引起。患者多在出生後六週內即頻繁發生癲癇。我們先前發現CDKL5缺失小鼠於出生後12天出現癲癇的徵狀，但隨即恢復正常。透過全基因組RNA序列分析，我們發現CDKL5缺失導致新生小鼠海馬迴中抑制性神經傳導相關基因的表現量下調，而離乳前小鼠皮質中GABA傳導相關基因的表現量卻上調。本計畫將首先確認CDKL5缺失是否透過海馬迴中抑制性神經傳導的減少而增加了出生後早期的神經興奮性(Aim 1)。然後探討CDKL5缺失小鼠在離乳前神經興奮性回復正常是否肇因於皮質中GABA傳導的提升(Aim2)。本計畫之研究成果將有助於發展不同年齡適用的療法來改善CDD的早發性癲癇。
    Relation: 國家科學及技術委員會, NSTC112-2320-B004-001, 112.08-113.07
    Data Type: report
    Appears in Collections:[神經科學研究所] 國科會研究計畫

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