政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/157158

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政大機構典藏 > 理學院 > 神經科學研究所 > 國科會研究計畫 > Item 140.119/157158

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/157158

Title:	探討N-甲基-D-天門冬胺酸受體調節劑對母體免疫激活的後代成年小鼠之精神缺陷和神經化學異常的療效及機轉 Investigating the Therapeutic Benefits and Mechanisms of N-Methyl-D-Aspartate Receptor Modulators on Psychiatric Deficits and Neurochemical Abnormalities in Adult Mouse Offspring after Maternal Immune Activation
Authors:	詹銘煥
Contributors:	神科所
Keywords:	行為異常;認知;電生理學;母體免疫激活;N-甲基-D-天門冬胺酸受體調節劑;精神疾病 Behavioral abnormality;Cognition;Electrophysiology;Maternal immune activation;NMDA receptor modulators;Psychiatric disorder
Date:	2023-09
Issue Date:	2025-05-29 11:56:48 (UTC+8)
Abstract:	本研究所檢測的動物精神行為異常相關的表現型特徵包含血液中單核細胞、麩胺酸關聯之胺基酸相對量或NMDA受體相關蛋白表達值將可作為神經精神病症的特別鑑別診斷，治療或症狀之生物標記。本計畫實驗將進一步支持補充NMDA受體調節劑，影響甘胺酸調整NMDA受體活性及下游神經訊息傳遞機制，如PI3K/AKT/GSK3，在母體免疫激活下，後代產生精神病的前驅期施予早期干預可以預防成年期精神病性的發作，改善後代的精神行為缺陷狀態及神經化學物質異常。未來研究的新發現將在新藥開發和新穎療法上開啟前瞻性領域，更符合精神疾病相關的預防暨臨床治療需求。
Relation:	科技部, MOST111-2320-B004-001, 111.08-112.07
Data Type:	report
Appears in Collections:	[神經科學研究所] 國科會研究計畫

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