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    Title: 拓展心衰竭專利藥普及率之商業策略
    Strategic Approached to Expanding the Accessibility and Adoption of Patented Medication for Heart Failure
    Authors: 范姜士彰
    Chiang, Allen Fan
    Contributors: 吳文傑
    Wu, Wen-Chieh
    范姜士彰
    Allen Fan Chiang
    Keywords: 心衰竭
    heart failure
    ivabradine
    Coralan
    patent
    life quality
    Date: 2025
    Issue Date: 2025-02-04 15:36:41 (UTC+8)
    Abstract: Heart failure is a condition caused by loss of crucial quantity of functional myocardial cells after injury to the heart from various causes. With a 5-year mortality rate ranks fifth among all diseases, heart failure is also a chronic condition that patients must live with but cannot be cured. Thus, the challenge lies in improving life quality for heart failure patients through medical treatment. With intervention of Ivabradine, patients can improve their heart’s ejection fraction and alleviate symptoms that interfere with daily life. Moreover, Ivabradine is currently the only solution to manage hypotension caused by heart failure, a condition that not only causes discomfort but also hinders patients from reaching target medication dose. Therefore, raising awareness of Ivabradine intervention is crucial to optimizing medication and improving life quality for eligible patients. Without a large budget, Servier, the patent owner of Ivabradine in Taiwan, can only conduct limited promotional activities. This thesis will focus on a case study of strategies to achieve a 17% national growth rate for 4 consecutive years, ultimately reaching 50% coverage of eligible patients before patent expires in 2028 with limited budget. More than incremental profits, the underlying goal is to take responsibilities of improving life quality for more patients by optimizing heart failure treatment with Ivabradine.
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    3. Vardeny O, et al. Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trial. Eur J Heart Fail 2016;18(10):1228-34.
    4. Pharithi RB, et al. Sacubitril-Valsartan in a routine community population: attention to volume status critical to achieving target dose. ESC Heart Fail 2020;7(1):158-66.
    5. Kitai T et al. Insufficient reduction in heart rate during hospitalization despite beta-blocker treatment in acute decompensated heart failure: insights from the ASCEND-HF trial. Eur J Heart Fail. 2017 Feb;19(2):241-249.
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    8. U.S. Food & Drug Administration
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    9. Parikh RR, et al. Effects of Digoxin in Heart Failure (HF) With Reduced Ejection Fraction (EF). Cureus. 2022 Mar 2;14(3):e22778.
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    11. Murphy SP et al. Heart Failure With Reduced Ejection Fraction: A Review. JAMA. 2020 Aug 4;324(5):488-504.
    12. Borlaug BA et al. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J. 2011 Mar;32(6):670-9.
    13.UpToDate.https://www.uptodate.com/contents/treatment-and-prognosis-of-heart-failure-with-preserved-ejection-fraction/print
    14. Swedberg K et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet. 2010 Sep 11;376(9744):875-85.
    15. Swedberg K et al. Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT). Eur J Heart Fail. 2010 Jan;12(1):75-81.
    16. 2023 Consensus of Taiwan Society of Cardiology on the Pharmacological Treatment of Chronic Heart Failure. Acta Cardiol Sin. 2023 May;39(3):361-390.
    17. Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study. Clin Res Cardiol. 2013 Jan;102(1):11-22.
    18. The Characteristics and Outcomes of Patients with Heart Failure and Reduced Ejection Fraction: The Eligibility of Novel Heart Failure Medications. Acta Cardiol Sin. 2021 Jul;37(4):394-403.
    19. TSOC-HFrEF Registry: A Registry of Hospitalized Patients with Decompensated Systolic Heart Failure: Description of Population and Management. Acta Cardiol Sin. 2016 Jul;32(4):400-11.
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    23. University of Oxford, Centre for Evidence-Based Medicine
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    24. Kansal AR et al. Cost-Effectiveness of Ivabradine for Heart Failure in the United States. J Am Heart Assoc. 2016 May 6;5(5):e003221.
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    26. Levine, H.J. (1997) Rest Heart Rate and Life Expectancy. Journal of the American College of Cardiology, 30, 1104-1106.
    27. Diaz, et al. Heart Rate Working Group. Resting heart rate in cardiovascular disease. J Am Coll Cardiol. 2007;50(9):823-830.
    28. Borer JS et al. Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT Study. Eur Heart J Online, 27 August 2012
    29. Fong MC et al. The Characteristics and Outcomes of Patients with Heart Failure and Reduced Ejection Fraction: The Eligibility of Novel Heart Failure Medications. Acta Cardiol Sin. 2021 Jul;37(4):394-403.
    30. Wang CC et al. TSOC-HFrEF Registry: A Registry of Hospitalized Patients with Decompensated Systolic Heart Failure: Description of Population and Management. Acta Cardiol Sin. 2016 Jul;32(4):400-11.
    31. Böhm M et al. Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study. Clin Res Cardiol. 2013 Jan;102(1):11-22.
    32. National Health Institute – Health Technology Assessment from Taiwan Center for Drug Evaluation
    https://www.nhi.gov.tw/ch/dl-11875-717e9c20986c419dbdb36346b2360fea-1.pdf?utm_source=chatgpt.com
    Description: 碩士
    國立政治大學
    國際經營管理英語碩士學位學程(IMBA)
    109933010
    Source URI: http://thesis.lib.nccu.edu.tw/record/#G0109933010
    Data Type: thesis
    Appears in Collections:[國際經營管理英語碩士學程IMBA] 學位論文

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