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    题名: Task-dependent effects of SKF83959 on operant behaviors associated to distinct changes of CaMKII signaling in striatal subareas
    作者: 廖瑞銘;趙知章
    Liao,  Ruey-Ming;Chao, Chih-Chang
    Liu, Pei-Pei
    贡献者: 心理系;神科所
    关键词: Atypical dopamine receptor agonist; dorsal striatum; neurochemical mechanism; nucleus accumbens; schedule-controlled behavior
    日期: 2021-09
    上传时间: 2022-02-10 11:39:12 (UTC+8)
    摘要: Background SKF83959, an atypical dopamine (DA) D1 receptor agonist, has been used to test the functions of DA-related receptor complexes in vitro, but little is known about its impact on conditioned behavior. The present study examined the effects of SKF83959 on operant behaviors and assayed the neurochemical mechanisms involved. Methods Male rats were trained and maintained on either a fixed-interval 30-second (FI30) schedule or a differential reinforcement of low-rate response 10-second (DRL10) schedule of reinforcement. After drug treatment tests, western blotting assayed the protein expressions of the calcium-/calmodulin-dependent protein kinase II (CaMKII) and the transcription factor cyclic AMP response element binding protein (CREB) in tissues collected from 4 selected DA-related areas. Results SKF83959 disrupted the performance of FI30 and DRL10 behaviors in a dose-dependent manner by reducing the total number of responses in varying magnitudes. Moreover, the distinct profiles of the behavior altered by the drug were manifested by analyzing qualitative and quantitative measures on both tasks. Western-blot results showed that phospho-CaMKII levels decreased in the nucleus accumbens and the dorsal striatum of the drug-treated FI30 and DRL10 subjects, respectively, compared with their vehicle controls. The phospho-CREB levels decreased in the nucleus accumbens and the hippocampus of drug-treated FI30 subjects but increased in the nucleus accumbens of drug-treated DRL10 subjects. Conclusions Our results provide important insight into the neuropsychopharmacology of SKF83959, indicating that the drug-altered operant behavior is task dependent and related to regional-dependent changes of CaMKII-CREB signaling in the mesocorticolimbic DA systems.
    關聯: International Journal of Neuropsychopharmacology, Vol.24, No.9, pp.721-733
    数据类型: article
    DOI 連結: https://doi.org/10.1093/ijnp/pyab032
    DOI: 10.1093/ijnp/pyab032
    显示于类别:[心理學系] 期刊論文
    [神經科學研究所] 期刊論文

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