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    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/128687


    Title: Knockdown of protein kinase CK2 blocked gene expression mediated by brain-derived neurotrophic factor-induced serum response element
    Authors: 趙知章
    Chao, Chih-Chang
    SP, Yang
    CY, Lo
    HM, Tseng
    Contributors: 神科所
    Keywords: Antiapoptosis;brain-derived neurotrophic factor;Mcl-1;protein kinase CK2;serum response element-mediated transcription
    Date: 2019-04
    Issue Date: 2020-02-20 11:56:22 (UTC+8)
    Abstract: One of the principal signaling pathway outcomes from brain-derived neurotrophic factor (BDNF) is the activation of antiapoptotic pathways. In addition to the role of extracellular signal-regulated kinase 1/2 and phosphatidylinositol-3 kinase, BDNF activates protein kinase CK2 to mediate its neuroprotective effect. The inhibition of CK2 activity has been shown to induce apoptosis. Although serum response element (SRE)-mediated transcription has been reported to be activated by BDNF and that the phosphorylation of serum response factor (SRF) by CK2 has been shown to enhance its DNA binding activity, the biological relevance of these interactions remains largely unclear. In the present study, we found that SRE-mediated transcription, CK2 activity, and SRF phosphorylation increased in PC12 cells under BDNF treatment. The transfection of CK2α siRNA blocked the enhancing effect of BDNF on SRE-mediated transcription, SRF phosphorylation, and Mcl-1 gene expression. Moreover, the blockade of CK2 diminished the antiapoptotic effects of BDNF on SRE-mediated transcription, Mcl-1 gene expression, and cell viability under rotenone-induced cytotoxicity. Our data may assist in the development of therapeutic strategies for inhibiting apoptosis during neurodegeneration.
    Relation: Chinese Journal of Physiology, Vol.62, pp.63-69
    Data Type: article
    DOI 連結: https://doi.org/10.4103/CJP.CJP_1_19
    DOI: 10.4103/CJP.CJP_1_19
    Appears in Collections:[神經科學研究所] 期刊論文

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