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    题名: Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan
    作者: 趙知章
    Chao, Chih-Chang
    MH, Wu
    CW, Tsai
    DT*, Bau
    YW, Hung
    CL, Gong
    TC, Yueh
    SC, Wang
    YL, Lai
    SW, Hsu
    WS, Chang
    贡献者: 神科所
    关键词: Case–control study;Taiwan;caspase-8;colorectal cancer;genotype;polymorphism
    日期: 2019-06
    上传时间: 2020-02-20 11:56:01 (UTC+8)
    摘要: BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis.
    關聯: Anticancer Research, Vol.39, No.6, pp.2791-2797
    数据类型: article
    DOI 連結: https://doi.org/10.21873/anticanres.13406
    DOI: 10.21873/anticanres.13406
    显示于类别:[神經科學研究所] 期刊論文

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