政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/125126

English | 正體中文 | 简体中文 | Post-Print筆數 : 27 | 全文笔数/总笔数 : 113648/144635 (79%)
造访人次 : 51578769 在线人数 : 956

RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

政大機構典藏 > 商學院 > 統計學系 > 期刊論文 > Item 140.119/125126

请使用永久网址来引用或连结此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/125126

题名:	Semiparametric variance components models for genetic studies with longitudinal phenotypes
作者:	Wang, Y. 黃佳慧 Huang, C.-H.
贡献者:	統計系
关键词:	Genome-wide linkage study;Multivariate longitudinal data;Penalized splines;Quantitative trait locus
日期:	2012-07
上传时间:	2019-08-13 09:19:19 (UTC+8)
摘要:	In a family-based genetic study such as the Framingham Heart Study (FHS), longitudinal trait measurements are recorded on subjects collected from families. Observations on subjects from the same family are correlated due to shared genetic composition or environmental factors such as diet. The data have a 3-level structure with measurements nested in subjects and subjects nested in families. We propose a semiparametric variance components model to describe phenotype observed at a time point as the sum of a nonparametric population mean function, a nonparametric random quantitative trait locus (QTL) effect, a shared environmental effect, a residual random polygenic effect and measurement error. One feature of the model is that we do not assume a parametric functional form of the age-dependent QTL effect, and we use penalized spline-based method to fit the model. We obtain nonparametric estimation of the QTL heritability defined as the ratio of the QTL variance to the total phenotypic variance. We use simulation studies to investigate performance of the proposed methods and apply these methods to the FHS systolic blood pressure data to estimate age-specific QTL effect at 62cM on chromosome 17.
關聯:	Biostatistics, Vol.13, pp.482-496
数据类型:	article
DOI 連結:	https://doi.org/10.1093/biostatistics/kxr027
DOI:	10.1093/biostatistics/kxr027
显示于类别:	[統計學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
64.pdf		435Kb	Adobe PDF2	221	检视/开启

在政大典藏中所有的数据项都受到原著作权保护.

社群 sharing

著作權政策宣告 Copyright Announcement

1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.

数据加载中.....