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政大機構典藏 > 理學院 > 神經科學研究所 > 期刊論文 > Item 140.119/120974

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/120974

Title:	Mullerian Inhibiting Substance contributes to sex-linked biases in the brain and behavior
Authors:	Wang, Pei-Yu;Protheroe, Anna;Clarkson, Andrew N.;Imhoff, Floriane;Koishi, Kyoko;McLennan, Ian S. 王培育 Wang, Pei-Yu
Contributors:	神科所
Keywords:	anti-Müllerian hormone;exploratory behavior;motor neuron;sexual dimorphism
Date:	2009-04
Issue Date:	2018-11-21 16:24:01 (UTC+8)
Abstract:	Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.
Relation:	Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.17, pp.7203-7208 PMID: 19359476
Data Type:	article
DOI 連結:	https://doi.org/10.1073/pnas.0902253106
DOI:	10.1073/pnas.0902253106
Appears in Collections:	[神經科學研究所] 期刊論文

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