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| Title: | Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia. |
| Authors: | 藍亭
Martino, Matteo
Magioncalda, Paola
Yu, Hua
Li, Xiaojing
Wang, Qiang
Meng, Yajing
Deng, Wei
Li, Yinfei
Li, Mingli
Ma, Xiaohong
Lane, Timothy
Duncan, Niall W.
Northoff, Georg
Li, Tao |
| Contributors: | 心理學系 |
| Keywords: | schizophrenia:substantia nigra:resting-state, fMRI:functional connectivity:slow frequency bands:neural synchronization |
| Date: | 2018-02 |
| Issue Date: | 2018-01-15 11:39:34 (UTC+8) |
| Abstract: | Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity. |
| Relation: | Schizophrenia Bulletin, Volume 44, Issue 2, Pages 419–431 |
| Data Type: | article |
| DOI 連結: | http://dx.doi.org/10.1093/schbul/sbx067 |
| DOI: | 10.1093/schbul/sbx067 |
| Appears in Collections: | [心理學系] 期刊論文
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