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Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/113627

Title:	Physical mechanism for biopolymers to aggregate and maintain in non-equilibrium states
Authors:	馬文忠胡進錕 Ma, Wen-Jong Hu, Chin-Kun
Contributors:	應物所
Keywords:	Biological physics;Molecular modelling
Date:	2017-06
Issue Date:	2017-10-16 12:10:49 (UTC+8)
Abstract:	Many human or animal diseases are related to aggregation of proteins. A viable biological organism should maintain in non-equilibrium states. How protein aggregate and why biological organisms can maintain in non-equilibrium states are not well understood. As a first step to understand such complex systems problems, we consider simple model systems containing polymer chains and solvent particles. The strength of the spring to connect two neighboring monomers in a polymer chain is controlled by a parameter s with s → ∞ for rigid-bond. The strengths of bending and torsion angle dependent interactions are controlled by a parameter s A with s A → -∞ corresponding to no bending and torsion angle dependent interactions. We find that for very small s A , polymer chains tend to aggregate spontaneously and the trend is independent of the strength of spring. For strong springs, the speed distribution of monomers in the parallel (along the direction of the spring to connect two neighboring monomers) and perpendicular directions have different effective temperatures and such systems are in non-equilibrium states.
Relation:	Scientific Report, Vol.7, pp.3105
Data Type:	article
DOI link:	http://dx.doi.org/10.1038/s41598-017-03136-7
DOI:	10.1038/s41598-017-03136-7
Appears in Collections:	[Election Study Center] Periodical Articles

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