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    题名: Regional differences in dopamine receptor blockade affect timing impulsivity that are altered by d-amphetamine on differential reinforcement of low-rate responding (DRL) behavior in rats
    作者: 廖瑞銘
    Cheng, Ruey-Kuang
    Liao, Ruey-Ming
    贡献者: 心理系
    关键词: Mesocorticolimbic DA systems;Response inhibition;Timing process;Dopamine receptor subtypes;Operant behavior
    日期: 2017-07
    上传时间: 2017-09-20 15:29:38 (UTC+8)
    摘要: The ability to control when to start an action and when to stop is crucial in human and animal behavior. A failure to suppress premature behavior or to carry out an action in a timely manner is commonly seen in several neuropsychological disorders. Despite the phenomenon, the exact neural mechanisms underlying this timing impulsivity remain to be elucidated. Systemic injection of d-amphetamine (AMP) has been shown to disrupt rat’s performance in the differential reinforcement of low-rate (DRL) task that requires both optimal timing and proper impulsive control as measured by peak time and non-reinforced responses, respectively. By directly infusing selective D1 or D2 receptor antagonists (SCH23390 and raclopride, respectively) into three brain areas, we aimed to uncover which brain regions and which dopamine receptor subtypes are involved in counteracting the rat’s deficit of DRL performance induced by the systemic injection of AMP. We found that D1, but not D2 receptors in the dorsal hippocampus (dHIP) and nucleus accumbens (NAC) played an important role in impulsive control as well as in timing. In the medial prefrontal cortex (mPFC), both D1 and D2 receptors played an equal role in impulsive control, but only mPFC D1 was critical in the control of timing. Together, our data revealed a regional-dependent and dopamine receptor subtype specific effect across each region tested in the mesocorticolimbic circuits on the deleterious effect of AMP in the DRL task. The current findings further advance our understanding of the neurobehavioral mechanisms involved in timing impulsivity.
    關聯: Behavioural Brain Research, Volume 331, Pages 177-187
    数据类型: article
    DOI 連結: https://doi.org/10.1016/j.bbr.2017.05.020
    DOI: 10.1016/j.bbr.2017.05.020
    显示于类别:[心理學系] 期刊論文

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