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政大典藏 > College of Science > Department of Psychology > Periodical Articles > Item 140.119/112530

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/112530

Title:	Evident cognitive impairments in seemingly recovered patients after midazolam-based light sedation during diagnostic endoscopy.
Authors:	楊啟正 Hsu, Yen-Hsuan Lin, Feng-Sheng Yang, Chi-Cheng Lin, Chih-Peng Hua, Mau-Sun Sun, Wei-Zen
Contributors:	心理系
Date:	2015-06
Issue Date:	2017-09-06 16:29:22 (UTC+8)
Abstract:	BACKGROUND/PURPOSE: Midazolam is a widely used sedative agent during colonoscopy, with cognitive toxicity. However, the potential cognitive hazard of midazolam-based light sedation has not been sufficiently examined. We aimed to examine the cognitive safety and vulnerability profile under midazolam light sedation, with a particular focus on individual variations. METHODS: We conducted a prospective case-controlled study in an academic hospital. In total, 30 patients undergoing sedative colonoscopy as part of a health check-up were recruited. Neuropsychological testing on the full cognitive spectrum was evaluated at 15 minutes and 120 minutes after low-dose midazolam administration. The modified reliable change index (RCI) was used for intrapersonal comparisons and controlling for practice effects.
Relation:	Journal of the Formosan Medical Association, Vol.114, No.6, pp.489-497
Data Type:	article
DOI link:	https://doi.org/10.1016/j.jfma.2013.07.018
DOI:	10.1016/j.jfma.2013.07.018
Appears in Collections:	[Department of Psychology] Periodical Articles

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