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题名:	Physical mechanism for biopolymers to aggregate and maintain in non-equilibrium states
作者:	Ma, Wen-Jong;Hu, Chin-Kun 馬文忠
贡献者:	應用物理所
关键词:	Biological physics;Molecular modelling
日期:	2017
上传时间:	2017-07-20 16:55:43 (UTC+8)
摘要:	Many human or animal diseases are related to aggregation of proteins. A viable biological organism should maintain in non-equilibrium states. How protein aggregate and why biological organisms can maintain in non-equilibrium states are not well understood. As a first step to understand such complex systems problems, we consider simple model systems containing polymer chains and solvent particles. The strength of the spring to connect two neighboring monomers in a polymer chain is controlled by a parameter s with s → ∞ for rigid-bond. The strengths of bending and torsion angle dependent interactions are controlled by a parameter sA with sA → -∞ corresponding to no bending and torsion angle dependent interactions. We find that for very small sA, polymer chains tend to aggregate spontaneously and the trend is independent of the strength of spring. For strong springs, the speed distribution of monomers in the parallel (along the direction of the spring to connect two neighboring monomers) and perpendicular directions have different effective temperatures and such systems are in non-equilibrium states. © 2017 The Author(s).
關聯:	Scientific Reports 7, Article number: 3105
数据类型:	article
DOI 連結:	http://dx.doi.org/10.1038/s41598-017-03136-7
DOI:	10.1038/s41598-017-03136-7
显示于类别:	[應用物理研究所 ] 期刊論文

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