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Title:	Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants
Authors:	Lin, Chih-Lin;Kao, Jia-Horng 林志陵
Contributors:	心理系
Date:	2017
Issue Date:	2017-07-20 15:20:28 (UTC+8)
Abstract:	Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice. © 2017 Elsevier Ltd.
Relation:	Best Practice and Research: Clinical Gastroenterology, Available online 5 May 2017
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1016/j.bpg.2017.04.010
DOI:	10.1016/j.bpg.2017.04.010
Appears in Collections:	[心理學系] 期刊論文

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