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    請使用永久網址來引用或連結此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/110180


    題名: N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice
    作者: 詹銘煥
    Lin, Jen-Cheng;Chan, Ming-Huan;Lee, Mei-Yi;Chen, Yi-Chyan;Chen, Hwei-Hsien
    貢獻者: 神科所
    關鍵詞: Anesthesia;Forced swimming;Glycine;NMDA receptor;Prepulse inhibition
    日期: 2016-11
    上傳時間: 2017-06-05 14:44:47 (UTC+8)
    摘要: Ketamine, a dissociative anesthetic, produces rapid and sustained antidepressant effects at subanesthtic doses. However, it still inevitably induces psychotomimetic side effects. N,N-dimethylglycine (DMG) is a derivative of the amino acid glycine and is used as a dietary supplement. Recently, DMG has been found acting at glycine binding site of the N-methyl-d-aspartate receptor (NMDAR). As blockade of NMDARs is one of the main mechanisms responsible for the action of ketamine on central nervous system, DMG might modulate the behavioral responses to ketamine. The present study determined the effects of DMG on the ketamine-induced psychotomimetic, anesthetic and antidepressant-like effects in mice. DMG pretreatment reversed the ketamine-induced locomotor hyperactivity and impairment in the rotarod performance, novel location and novel object recognition tests, and prepulse inhibition. In addition, DMG alone exhibited antidepressant-like effects in the forced swim test and produced additive effects when combined with ketamine. However, DMG did not affect ketamine-induced anesthesia. These results reveal that DMG could antagonize ketamine`s psychotomimetic effects, yet produce additive antidepressant-like effects with ketamine, suggesting that DMG might have antipsychotic potential and be suitable as an add-on therapy to ketamine for patients with treatment-resistant depression.
    關聯: Prog Neuropsychopharmacol Biol Psychiatry., Vol.71, pp.7-13
    資料類型: article
    DOI 連結: https://doi.org/10.1016/j.pnpbp.2016.06.002
    DOI: 10.1016/j.pnpbp.2016.06.002
    顯示於類別:[神經科學研究所] 期刊論文

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